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KMID : 1044720110010010040
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Journal of Lifestyle Medicine
2011 Volume.1 No. 1 p.40 ~ p.46
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Serum Uric Acid Levels within the Normal Range Are Independently Associated with Metabolic Syndrome in the Korean Community-Based Cohort
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Lee Eun-Young
Lee Mi-Young
Koh Sang-Baik
Ahn Song-Vogue
Chung Choon-Hee
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Abstract
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Background: Hyperuricemia has been considered a common feature in patients with metabolic syndrome, however, there have been few reports linking normal serum uric acid levels with metabolic syndrome. In this study, we investigated whether serum uric acid level was associated with metabolic syndrome and insulin resistance in the general population, especially in subjects within the normal range of serum uric acid levels.
Methods: A total of 4,533 participants aged 40 years and over from the community-based cohort, Korean Rural Genomic Cohort, were included. Serum uric acid and other clinical and biochemical metabolic parameters including adiponectin, alcohol intake, γ-glutamyltransferase, body mass index, and C-reactive protein were measured.
Results: In men, compared with those in the lowest uric acid quartiles (≤286 μmol/l), participants in the third quartile (334-387 μmol/l) had 1.5-fold risk of metabolic syndrome and participants in the highest quartile (men ≥388 μmol/l) had 2.0-fold risk of metabolic syndrome. Similarly, in women, compared with those in the lowest uric acid quartiles (≤208 μmol/l), participants in the third quartile (239-280 μmol/l) had 1.6-fold risk of metabolic syndrome and participants in the highest quartile (≥281 μmol/l) had 2.8-fold risk of metabolic syndrome. We also found that serum uric acid increases with the body mass index, alcohol intake, γ-glutamyltransferase, and decreases with adiponectin.
Conclusions: These results suggest that uric acid levels, including levels within normal range, may be surrogate markers of metabolic syndrome in the general population.
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KEYWORD
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Uric acid, Metabolic syndrome, Hyperuricemia, Epidemiology
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